Deerland Enzymes


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The Not-So-Subtle Clinical Results of B. subtilis DE111®

Category: Educational Articles

Probiotics, as science continues to reveal, are as individual as people. Each strain has a range of unique proficiencies, allowing for condition-specific support and relevance in modern lifestyles.

One particularly exciting strain is a genome-sequenced and clinically tested strain of Bacillus subtilis (called DE111), a probiotic spore that concentrates its actions on bolstering immune function and digestive stability by, in part, controlling microbial populations (acting as a competitive exclusionary agent). It also has a unique ability to form spores that protect the microbes from harsh conditions through to the destination where they can germinate robustly – the GI tract.

Here is a characteristic that makes DE111 attractive – its spore-forming action ensures this probiotic remains viable in a wide range of pH and temperatures, ensuring its efficacy and stability in an array of health products consumers are gravitating toward, such as foods and beverages. Even as functional foods grow in number and in appeal, consumers still heavily rely on supplements in the form of capsules to obtain the nutrients they deem important.

A clinical trial recently conducted on DE111 showed that in capsule form, the probiotic was well tolerated and efficacious. In the study, 41 healthy college students consumed one capsule per day that contained approximately 5 billion colony forming units (CFU) of B. subtilis DE111 in addition to their usual diets. Blood levels of important biomarkers were measured. Markers of systemic acceptance, such as CRP and liver enzymes, remained within acceptable ranges and the participants reported that GI symptoms and bowel habits improved with probiotic capsule consumption. In addition, the DE111 supplement resulted in a significant effect on gut microflora measured prior to and after capsule consumption.

What we at Deerland found very interesting is that, during the course of the study, the volunteers underwent finals, a time notorious for high stress and poor eating habits. As we all know, it only takes a few days for high-stress and junk food to aggravate our GI systems. We are inspired by these study results as we can see how DE111 is even able to maintain healthy levels of cholesterol, glucose and triglycerides through times of high stress.

This study adds to a considerable cache of safety studies, including genome mapping, antibiotic resistance analysis and gene transfer analysis. As such, DE111 is Non-GMO Project Verified, and has been approved by Health Canada with the issuance of a Natural Product Number (NPN 80077102).

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