Genome Sequencing Can Help Identify Undesirable Traits in Probiotic Strains

Genome sequencing is a laboratory process that can be performed with any full copy of DNA. Determining the DNA sequence of an organism can help reveal what each gene making up a genome does, how different genes interact, and how the various parts of the genome are coordinated. By breaking down the sequence, probiotics can be tested for safety and effectiveness, as well as the presence of undesirable traits such as deleterious genes, antibiotic-resistant genes, and plasmids. Sequencing essentially reveals everything there is to know about a bacterial strain.

First, genome sequencing helps identify any deleterious genes that may be present in a probiotic.  Deleterious genes can cause health problems that compromise the capacity of afflicted individuals.

Breaking down the genomic sequence can also identify if the bacteria contains antibiotic-resistant genes. It is important that a supplemental probiotic NOT contain antibiotic-resistant genes. This may seem counterintuitive; shouldn’t you want your probiotic to survive in the gut?  Of course.  However, the fact is that gut bacteria can transfer genetic material among one another. The undesirable bacteria in the gut could acquire antibiotic-resistant genes from other, often harmless, bacteria. Because bacteria containing antibiotic-resistant genes do not respond to specific antibiotics, an infection may be untreatable if caused by antibiotic-resistant bacteria. The increasing number of life-threatening infections caused by antibiotic-resistant bacteria is triggering a rapidly growing global health problem.

Finally, the sequence examines plasmids present in a probiotic strain. A plasmid is a naturally occurring small DNA molecule within a cell that can replicate independently. When a bacterium divides, all the plasmids contained within the cell are copied, such that each daughter cell receives a copy of each plasmid. Bacteria can also transfer plasmids to one another through a process called conjugation. The genes carried in plasmids provide bacteria with genetic advantages, such as resistance to antibiotics or heavy metals—while these new traits may provide an advantage for the organism, they may carry negative consequences for the host.

Genome sequencing is a beneficial tool to better understand any microorganism, including a probiotic. Not only does it help identify any undesirable traits, sequencing reveals genes that support beneficial functions, such as the production of IgG and IgA antibodies for immune response. Armed with the exact makeup of a probiotic, product formulators can make informed decisions and feel confident about the safety and function of the strains they choose for supplement products.

As a producer of probiotic solutions, Deerland Enzymes and Probiotics has put its DE111® probiotic to the test for undesirable traits. Through Deerland’s partnership with Cornell University, DE111 has been fully sequenced for safety and has been uploaded to GenBank, the National Institutes of Health genetic sequence database. By applying genome sequencing to probiotic research, Deerland is able to verify that the highly effective strain of Bacillus subtilis DE111 contains no undesirable traits.

DE111 offers immune system support and helps maintain a healthy gut. Learn more about DE111 and why it’s a superior probiotic at

Have a (Healthy) Heart!

February is national heart health awareness month, and the media has done a very effective job of delivering key messages to adult Americans about how and why to take care of their cardiovascular systems…especially those who have a family history of heart disease, have spent years smoking, and/or have spent years being obese and inactive (and who have lost weight or are losing weight).

There are startling statistics about the perils of heart disease in American adults (courtesy of the American Heart Association), especially when it comes to women:

  • 90 percent of women have one or more risk factors for developing heart disease.
  • Since 1984, more women than men have died each year from heart disease and the gap between men and women’s survival continues to widen.
  • An estimated 44 million women in the U.S. are affected by cardiovascular diseases.
  • Women have a higher lifetime risk of stroke than men.

But here’s a statistic that we can all find encouraging: 80 percent of heart disease and stroke events may be prevented by lifestyle changes and education.

Beyond dietary changes such as adding omega 3 EFA-containing foods (marine and plant based), cutting down on sodas, energy drinks, alcohol and coffee, and exercising – taking heart-healthy supplements also strengthen the foundation for promoting cardiovascular wellness.

Supplements known for promoting heart health are DHA/EPA, tocotrienols/tocopherols (vitamin E), coenzyme Q10, phytosterols and red wine polyphenols – but there are enzymes that help too.

There are enzymes that science suggests are cardioprotective. For example, bromelain has been shown in some studies to reduce blood platelet aggregation (clumping). This is important because blood clumping reduces blood flow to and from the heart.

The enzyme nattokinase also has cardio benefits: human studies have found that this enzyme may promote healthy blood pressure and may reduce clotting factors. Additionally, the proteolytic enzymes bromelain, nattokinase (and a few others) have antithrombotic, anticoagulant and anti-inflammatory activities, which make them valuable in overall cardiovascular-support formulas.

Other heart-friendly supplemental enzymes are lipase, which breaks down fat, such as triglycerides, and thus improves fat utilization; and papain, which supports normal inflammatory response.

Additionally, free radicals can contribute to cardiovascular stress. Free radicals are highly unstable molecules that oxidize other molecules – and oxidation is an undesirable reaction in the body, which can cause a host of problems if not held in check via antioxidants. Free radicals are produced in the body normally as part of metabolism, but when oxidized can lead to oxidative stress by the constant production of free radicals.

The body has an antioxidant defense system that helps maintain a healthy balance of reduced/oxidized antioxidants, and research suggests that maintaining this system may reduce development of disease. Glutathione, the most researched and protective molecule, and cysteine, are key components of this system.

The glutathione (GSH) antioxidant system – a critical component of a proprietary enzyme supplement formula, ThioZyme®AO – contributes directly to the disarming of reactive oxygen compounds and maintains, in reduced active form, vitamins C and E, which also exert an antioxidant effect.

Enzymes definitely provide more value to human health than aiding in digestion – cardiovascular wellness is a lovely bonus!

How to Manage Inadvertent Exposure to Gluten

Millions of people around the world suffer from allergies or intolerance to gluten. To avoid a potentially serious reaction, many of these individuals avoid gluten in their diets, including products that could possibly contain trace amounts of gluten. Despite best efforts, however, gluten can still be accidentally ingested. Gluten is not inherently difficult to digest for those with a healthy digestive system, but those individuals who are gluten intolerant can experience extreme discomfort, with symptoms that typically include a distressed GI tract and may manifest similar to irritable bowel syndrome (which can vary in severity dependent on the amount consumed and sensitivity level), and more severe reactions, such as rashes and nerve pain. Fortunately, there are measures that can be taken to help manage these symptoms, along with methods to better prepare the body to handle such occurrences.

Gluten actually consists of several different proteins, with the two main being gliadin and glutenin. Due in part to gliadin’s large peptide chain, gluten proteins can be extremely difficult for some people to digest, hence the term gluten intolerance. Undigested gluten may trigger an immune response in gluten intolerant individuals which, depending on the individual’s sensitivity, can cause the immune system to attack the inner lining of the small intestine. But maintaining a 100% gluten-free diet is extremely difficult. Many different foods contain gluten, and due to the nature of modern food production, it is virtually impossible to guarantee that no cross contamination occurs. These factors mean that accidental or inadvertent exposure to gluten is a very real, and for those with gluten intolerance potentially serious, possibility. However, there are options that offer some protection from accidental gluten exposure.

If a gluten intolerant individual inadvertently ingests gluten, there is no miracle antidote. Because everyone’s body reacts differently, there isn’t a quick fix; yet, by keeping hydrated and taking probiotics and digestive enzymes, it is possible to prevent and/or relieve symptoms. Digestive enzymes and probiotics have shown promising results in helping to better digest gluten proteins. Digestive enzymes target those difficult to digest peptide bonds in gluten proteins by breaking them down, making them easier to digest, while a regular intake of probiotics is essential for a healthy, robust gut that is better able to digest the broken down gluten proteins. Proactive measures such as these can also safeguard against the potential side effects of accidental consumption.

In addition, there are a few natural aids available to help manage intestinal symptoms after gluten ingestion. Drinking green or peppermint tea can ease a churning stomach, and marshmallow root can sooth stomach and gas pain. Studies have also shown that fasting for a couple of days after ingestion may help ‘reset’ your immune system; however, check with your doctor prior to trying this approach.

Even though there is no magic solution to inadvertent gluten exposure, it is possible to prepare your body for the worst. Working with a physician to develop a long-term strategy to rebuild and maintain gut health may include diet changes augmented by supplements, particularly probiotics which are essential for healthy, efficient digestion, and digestive enzymes which are specially formulated to combat those tough to break down peptide chains in gluten proteins. Using these tools to boost your digestive tract can help soften the side effects of exposure for those with gluten intolerance, and help others who simply wish to support their bodies’ natural digestion process.

Glutalytic is an enzyme supplement that goes beyond the traditional DPP IV (dipeptidyl peptidase IV) enzyme, offering superior degradation of the gluten proteins that cause immune responses. This unique proteolytic enzyme blend targets the internal and external peptide bonds that make up the gluten protein, helping to protect in the event of gluten ingestion. To learn more about Glutalytic and how it works, visit

DE111®: Promotes Healthy Regularity

Nobody really likes extremes – such as extremely hot and humid days in the summer to bitter, Arctic cold in the winter, or a too-sweet or too salty food. And, even occasional constipation and its opposite, diarrhea, is no picnic, either.

The “occasional irregularity” when it does occur, swiftly causes discomfort, sometimes even angst, depending upon the person’s situation (working outdoors, for example, and not being near a bathroom when the “feeling” hits.)

The gastrointestinal system is often quite persnickety. It is somewhat akin to a highway – sometimes traffic snarls and clogs, and sometimes when it’s empty, there’s always that show-off speeder who zooms by.

When one deals with both on a more frequent basis, this is the hallmark of irritable bowel syndrome (IBS), which is a medical diagnosis. In absence of IBS, people can become constipated due to medications (antidepressants, pain relievers, iron supplements), lack of sufficient fiber in the diet and hormone fluctuations. Occasional diarrhea not caused by pathogenic bacteria or virus is caused by stress and anxiety (which alters hormone release affecting the GI tract), some prescriptions, and some foods the individual may be sensitive to.

Preventing the occasional irregularity is desirable for multiple millions of healthy Americans who just don’t have time for “bathroom issues.” And, we have a new study, published in the Journal of Probiotics & Health, that shows our DE111® is such an effective solution.

The study included 50 individuals who supplemented with a placebo or one capsule of Bacillus subtilis DE111® supplying 1 billion CFU for 105 days. The participants supplied stool samples that were scored based on the Bristol Stool Chart index, kept a detailed food diary and filled out questionnaires.

The DE111 supplemented group experienced a modulation of bouts of constipation and diarrhea, showing a healthier bowel index – but no change in alternating constipation and diarrhea for the placebo group. Specifically, the proportion of normal stools increased from 37% to 43% in the DE111 group, while the proportion of normal stools remained the same in the placebo group. Interestingly, men taking DE111 had dramatic results – normal stools in this group inclined from 56% to 80%. The supplement also delivered similar impact on those participants 30 and older.

For consumers mindfully living a healthy lifestyle, the occasional extreme of constipation and diarrhea can be less than, well, occasional.

About DE111®
DE111 is a genome-sequenced and clinically tested strain of Bacillus subtilis, a probiotic spore that supports digestive and immune health. The genome sequencing confirmed the strain contained no plasmids, antibiotic resistant or deleterious genes; the human clinical studies showed the strain’s ability to control microbial populations, aid in digestion and maintain general health. DE111 is able to form spores that protect the microbes from harsh conditions until they enter an environment ripe for germination, such as the GI tract. Because of this spore-forming ability, DE111 remains viable under a wide temperature and pH range, making it ideal for use in supplements as well as food and beverages.

How To Get The Maximum Benefits From Your Probiotic Supplement

Probiotics are live microorganisms that adhere to the digestive tract, and can aid in digestion while supporting a strong immune system. A truly healthy gut may have more than 500 species of these “good bacteria”. If a person is suffering from issues related to the digestive system, such as diarrhea or constipation, they may benefit from replenishing these organisms by taking a probiotic supplement. However, just casually taking any probiotic won’t necessarily allow users to reap the full benefits, so let’s take a look at how to maximize the effectiveness of probiotic supplements.

The effectiveness of probiotics is often tied to whether they survive through the gastrointestinal tract. A 2001 study found that the factors which most impact their survival relate to the degree of stomach acidity, the length of time exposed to the acid, and exposure to bile salts. Different strains react differently to various pH and temperature levels; some are more sensitive than others. For example, spore-forming bacteria such as Bacillus subtilis have the ability to form spores that protect the microbes from harsh conditions until they enter an environment ripe for germination, such as the GI tract. Another study from 2011 found that probiotics fared better when taken with or just before a meal containing some fats. The theory is that the fat content of food increases the protective effect of a probiotic by providing the bacteria with a buffer against the acidity of the stomach.

Dosages can vary so it’s important to read labels. Colony forming units, or CFUs, indicate the bacterial count found in each capsule. An average probiotic dose is around 1–5 billion CFU, with high-dose probiotics ranging from 30 to 450 billion or more. While a low-dose probiotic can be great for a general maintenance program, a much higher dose is usually required to address particular conditions.

However, it’s not just the dosage that is important. Some probiotic strains are less hardy and die out faster, so it’s prudent to consider a multi-strain product with a few distinct strains. Some common strains are Lactobacillus and Bifidus, but there are typically several different species within these categories, and each offers specific benefits and characteristics that can be beneficial when working together.

Prebiotics are another way to improve the effectiveness of probiotics. They help nourish and encourage probiotics to colonize in the digestive tract. Prebiotics are found naturally in foods such as bananas, honey, whole grains, and garlic. Prebiotic dietary supplements are also available, but many are fibers and carbohydrates that require unreasonably large doses to be effective.  Non-fiber prebiotics, such as the mechanism found in the ingredient PreforPro, can offer all the benefits of a prebiotic quicker and more effectively, without the drawbacks of the typical fibers.

Millions take probiotic supplements regularly to encourage better gut health. But taking them, even daily, may not be providing all the benefits you expect. Optimize their impact by understanding additional ways to boost probiotic effectiveness.

Deerland Enzymes & Probiotics offers the strain Bacillus subtilis DE111®, a probiotic spore that is clinically proven for its effects on digestive and immune health. It is a highly effective complement to many of the non-spore strains on the market today.

Why 2018 Is the Year to Get Your Digestive Tract Back on Track

You may be surprised to learn that your body is jam packed with trillions of bacteria. But don’t worry, most of these bacteria in your body are located in your gut, and they are actually doing good work for you! This little ecosystem, referred to as the gut microbiome, is constantly working to improve your digestion, enhance your immune system, and protect you from harmful bacteria, all three of which are great reasons to focus on improving your gut health this year. The impact of gut health on overall well-being has been a very newsworthy topic in recent years. If you’ve been following the research and developments up until now, but haven’t taken the next step, then 2018 should be your year to do so, and here’s why.

The positive impact of a healthy gut has been proven time and time again. The gut microbiome contains thousands of different kinds of microbes, and is unique to each person. Strains of both good and bad bacteria exist in a delicate balance that effects your whole body. Not enough good bacteria, and functions such as digestion begin to degrade, leading to poor nutrient absorption, gas and bloating, even mental fogginess and weight fluctuations. With more good bacteria, functions such as digestion obviously improve, along with other functions that occur outside your gut, such as your ability to burn and store fat.

A healthy gut is not achieved from its bacterial make-up alone. Enzymes work with the gut microbiome to break down food into absorbable nutrients. If the body experiences a digestive enzyme deficiency, a healthy diet can go to waste as nutrients are not broken down and put to use in the body.

One of the most universally recommended methods to improve your gut health is through the use of enzymes and probiotics, good bacteria, either in foods or supplements. Without a healthy gut, a healthy diet can only go so far.

The long-term effects of a healthy gut can impact every part of your life. The GI tract is almost like a second brain, affecting moods, energy levels, libido, creative output, etc. Gastrointestinal health is extremely important to your overall well-being, which is why enzymes and probiotics are essential to restoring your intestines to a more optimal state. This can be achieved through both enzyme-rich raw foods and supplements.

But simply purchasing any supplement won’t solve your problems. When buying supplements, it is important to look at what they contain, and how much of it. When it comes to probiotics, be sure to check the specific strains and the Colony Forming Unit (CFU) number, which indicates the number of viable bacterial cells in each serving, to make sure that the supplement you choose is powerful enough to impact the flora in your gut.  For enzymes, be aware that the potency of these ingredients isn’t measured in milligrams as you may be accustomed to seeing, but instead in varying Activity Units. A supplement facts panel that lists its enzymes measured by weight (in milligrams) may not have a high enough activity to make the difference you’re seeking.

Whether your preferred delivery method is foods or supplements, improving your gut health should be resolution #1 for a healthier 2018.

Deerland Enzymes & Probiotics is a leading specialty formulator and contract manufacturer of enzyme- and probiotic-based dietary supplements. With a team of industry experts working in a state-of-the-art lab, we’re positioned to serve customers from the initial stages of product conceptualization, through the design phase, and on to final formulation and contract manufacturing.

Product Labeling: Matching What’s Outside With What’s Inside

When you only have a few seconds to grab the attention and influence a customer to buy, your label can make or break that sale. Product labels capture the eye, educate the consumer, and reinforce brand messaging, providing an unparalleled opportunity for brands to engage and connect with consumers. As the product’s face, labels can be used to target a market’s specific needs. And because most consumers associate quality with appearance, the visual elements of a label should be as compelling as possible, requiring a comprehensive investment in its design.

There are a great many moving parts when it comes to designing a label. Logos, content, fonts and even colors can influence a buyer’s purchasing decision. In fact, according to the Global Journal of Management and Business Research, certain colors generate different responses in viewers, with each color having the ability to affect certain emotions. For example, blue is considered calming, green is associated with nature, and yellow is thought to be arresting. Furthermore, a label should instantly communicate what your product and brand stand for, as well as the personality of your company. Label appearances should also correlate with the particular retail distribution channel, i.e. a specialty store, a chain, or an individual. Additionally, labels should be aesthetically striking enough to capture consumer attention but clear enough to communicate relevant information to the consumer.

In addition, certain specific features, such as QR codes, can make labels more eye-catching, even interactive, providing an innovative way for consumers to interact with and/or acquire more information about a product. Requiring very little label space, QR codes can open up videos, messaging, instructions, and further product or brand education.

In the supplements and nutraceuticals sector, labels are even more crucial as conscientious consumers prefer to know ingredient specifics. This can be as simple as product certification keywords like ‘organic’ or ‘non-GMO’, or as complex and necessary as active ingredients and potential allergens.  While labeling is a key form of advertising, designed to persuade customers to make a purchase, supplement labels must, of course, adhere to FTC guidelines which require product information to be “truthful, not misleading, and substantiated.” It’s safe to say– be clear, concise, and skip the hyperbole.

Here are a few other suggested guidelines to consider when designing supplement labels;

  • Labeling (including the ingredient list) should be clean and simple.
  • Authenticity is important, so designs should be original and straightforward.
  • Don’t forget about trends or current buzzwords, such as ‘Sustainability’.

Additionally, in an increasingly eco-conscious world, using multi-use packaging keeps your brand rotating while saving consumers money. And incorporating packaging made from recycled materials or that can be recycled reduces carbon footprint.

Simultaneously attracting customers, marketing your brand, and conveying product information, labels are an essential communication tool for your business. And because customers know and appreciate good, authentic branding, they are willing to pay more for it.

At Deerland, we take the regulatory requirements of labeling seriously.  Our regulatory team assists our customers in the review of their product labels, helping them ensure that their labels meet all regulatory requirements.  To learn more about the commercialization services we offer, visit

Branded Ingredients Build Trust and Cleaner Labels

Manufacturers of dietary supplements can win consumer interest and trust by making use of branded ingredients whenever possible. A branded ingredient has a unique identity and offers differentiated benefits over its generic counterpart. These attributes differentiate branded ingredients from commodity products—uniqueness, research, patents, regulatory status, formulation expertise and marketing dollars.

According to Innova Market Insights, 75% of Americans report that they read vitamin labels before choosing a product, and almost the same number of people strongly agree that nutritional labels should contain ingredients that are recognizable to the average consumer.

Using branded ingredients as a differentiating factor and identifying them on product labeling proves a company’s commitment to quality and transparency.

Branded ingredients support the clean label movement by making it possible for consumers to perform research on the product they intend to purchase. When consumers see a branded ingredient on the label, they can go look it up online, review the research, and see the data to support what they’re looking for. Informed shoppers are more likely to seek out and purchase products with branded ingredients.

The very best branded ingredients can tell a story that passively yet effectively wins consumer confidence. In researching the branded ingredient, consumers can discover scientific studies and clinical evidence that support marketing claims. Would-be buyers learn about the ingredient’s regulatory status, safety and efficacy, which in turn shape and strengthen their perception of the product itself.

Of course, the story told by a product is just as important to the retailers selling it as it is to the consumers buying. Retailers want products that intrigue consumers and attract them to their website or stores. They want products capable of winning a consumer’s trust, betting that they transfer that trust to the seller.

In today’s shopping culture, brand is closely linked to a buyer’s notion of quality. The term “generic,” by contrast, connotes something cheaper, something mass-produced and without a specific buyer in mind. Brand is a cut above generic. It commands a higher price. Positive interactions with a specific brand foster consumer loyalty and lead to repeat transactions.

Your Partner for Proven, Branded Ingredients

Add value, scientific support, and transparency to your products by formulating with branded ingredients. Don’t know where to start? At Deerland, we can help—from the initial stages of product conceptualization, through design phase, formulation, and even manufacturing. Our branded ingredients include science-backed enzyme blends, a probiotic and a prebiotic that support digestive health.

Our product innovation and customization will give you the edge you need to stand out from the competition. Visit today to learn more!

Deerland’s DE111® Probiotic Supports Regularity, According to Latest Study

Researchers have found that consumption of Deerland Enzymes and Probiotics’ probiotic strain DE111® can improve occasional constipation and/or diarrhea in healthy individuals, according to a study recently published in the Journal of Probiotics & Health.

In the study, 50 participants were evaluated over the course of 105 days by their stool profile, food diary and questionnaire while taking either a supplement capsule of Bacillus subtilis DE111® (1 billion CFU), or a placebo. The stools were scored based on the Bristol Stool Chart index and safety was assessed using blood markers. Statistically significant results showed that participants in the group taking DE111 moved to a healthier bowel index, while no change was observed with those in the placebo group.

The results of the study showed a reduction of alternating constipation and diarrhea for the participants taking DE111 when compared to participants taking the placebo. The proportion of normal stools (types 3 and 4) increased from 37% to 43% in the DE111 group, while the proportion of normal stools remained the same in the placebo group. In male participants specifically, the proportion of normal stools increased from 56% to 80%. In addition, a significant difference between the DE111 and placebo groups was observed in regards to normal and non-normal stool proportions in the 30+ age group.

“Bacteria make up more than 50% of the composition of a healthy person’s stool, and play a major role in the quality and frequency of bowel movements,” said Dr. John Deaton, vice president of science and technology at Deerland Enzymes and Probiotics. “Determining specific strains, such as DE111, that support regular and healthy bowel movements is beneficial in developing a probiotic formulation for digestive health.”

DE111 is a genome sequenced and clinically tested strain of Bacillus subtilis, a probiotic spore that supports digestive and immune health. The genome sequencing confirmed the strain contained no plasmids, antibiotic resistant or deleterious genes; the human clinical studies showed the strain’s ability to control microbial populations, aid in digestion and maintain general health. DE111 has the ability to form spores that protect the microbes from harsh conditions until they enter an environment ripe for germination, such as the GI tract. Because of this spore-forming ability, DE111 remains viable under a wide temperature and pH range, making it ideal for use in supplements as well as food and beverages.

Global Probiotic Market Shows Promising Signs of Continued Growth

For years, people have been encouraged to educate themselves and take control of their own health. Until recent years, this advice was often ignored by the masses. Fortunately, with more accessible information, the increase in access to personal health data, and new tools to make health information easier to digest, many individuals are becoming their own advocates.

As this shift continues, many consumers are turning to supplements to help maintain their wellbeing, and this phenomenon is not relegated to the United States alone. Between 2014 and 2015, sales of supplements worldwide grew 8% to a staggering $88.3 billion, and this growth is projected to increase. This market increase makes perfect sense, as health supplements such as probiotics are safe and affordable ways for consumers to have some control over their own health and vitality without radically changing their lifestyles.

Probiotics are naturally occurring microorganisms that inhabit the digestive tract and provide a myriad of beneficial and necessary functions vital to our wellbeing. This includes improving the immune system and intestinal tract. With a growing global population and awareness of these health benefits, the probiotic supplement industry has a bright future.

As a sector with a wide public and scientific following, probiotic supplements are expected to ride this wave of growth, according to the global market research company Euromonitor. However, many possible geographic market areas are hampered by cost issues, lack of access, and an absence of knowledge about probiotic benefits. There is also the question of delivery method. Currently, global sales of probiotic foods such as yogurt and sour milks exceed $41 billion. Sales of probiotic supplements now reach $3.8 billion. Compared to food products, supplements are an efficient delivery method for probiotics, so as more consumers learn about the effectiveness and ease of supplement use, the consumption gap between the two is projected to narrow.

By 2020, the global probiotics market is expected to reach $52.34 billion, up from just $32.06 billion in 2013, making it one of the fastest growing global markets. One of largest prospective markets for probiotics is the Asia Pacific region, which accounted for an estimated 38% share of the global probiotics market in 2016. This part of the world lacks widespread awareness about probiotics, and the opportunity exists for new health-awareness campaigns for consumers to ensure the market continues to grow. Some underdeveloped markets are looking at huge growth projections, such as the Middle East and Africa, both of which are anticipated to grow 126% over the next five years.

For many regions, this bright future will rely heavily on marketing to communicate the advantages of probiotic supplements over food options. Many regions already have popular probiotic foods, yet few probiotic supplements. Latin America, for example, has 97% of its probiotic market claimed by yogurt, and only 1% by supplements. The story is similar in Asia. Understanding what consumers want and who influences their purchases will be critical for probiotic manufacturers, brands, and retailers.

Currently, the United States, Italy, Russia, Japan, and Taiwan hold a combined 77% of the global probiotic retail market. As a result, there is still a huge area of untapped market potential around the globe. Increased scientific evidence to support probiotic health benefits, specialty strains to improve targeted action, and new delivery systems will help expand the worldwide adoption of probiotic supplement use.

Keeping track of these global probiotic trends is vital for understanding and preparing for the future of this rapidly expanding industry, which promises to keep growing thanks to continuing awareness, marketing, and a supportive regulatory climate.

Deerland Enzymes & Probiotics is a leading specialty formulator and contract manufacturer of enzyme and probiotic-based dietary supplements. With a team of industry experts working in a state-of-the-art lab, we are poised to serve our customers from the initial stages of customized product conceptualization, through the design phase, final formulation phase and contract manufacturing services. We make significant investments in working with our customers at the early concept phase of product development to ensure a thorough understanding of the benefits customers are focused on delivering to their consumers. From there, we’re able to customize a solution specific to our customer’s individual needs. To learn more, visit