White Paper: Why Probiotic Gummies Should Be in Your New Product Line Up

Combining the market growth of probiotics with the increasingly popular gummy delivery system is a market opportunity that shouldn’t be missed! Download this whitepaper to learn more about how Bacillus subtilis DE111 can help you combine probiotics with the gummy delivery system – a match made in supplement marketing heaven.

Click the image below to download.

It Takes Two: Probiotics and Enzymes for Digestive Balance

Some people believe that a life well lived is a life that has been in balance. Physically, good health is called “homeostasis,” which primarily means that everything is in balance.

Yin-yang is the concept of balance; dark to light. And who can forget the oft-uttered phrase of one of filmdom’s most beloved characters, Forrest Gump, who proclaims his most cherished relationship with Jenny was like “peas and carrots.”

Well, it’s the same with enzymes and probiotics. Much of the spotlight shining on supplements for good health has been on probiotics, and for very good reason; accelerated research continues to demonstrate efficacy of many probiotic strains and prebiotics in supporting digestive and immune health, among other newer biological areas.

For example:

  1. A unique Bacillus subtilis strain has been shown to crowd out irrelevant bacteria via supporting normal immune reaction of intestinal cells and communicating with intestinal cells to maintain healthy functioning of the gut barrier. A clinical study investigated the effects of 5 billion CFU B. subtilis DE111® in the gut microflora. Samples showed not only that there was a healthy increase in both B. subtilis and bifidobacteria, but that it appeared to support the normal breakdown of complex carbohydrates, sugars and fats, thereby enhancing digestive function. Another study showed that individuals who fluctuated between constipation and loose stools who took 1 billion CFU of the B. subtilis DE111 experienced more normalized stools, compared to those in the placebo group.
  2. PreforPro® is a wholesome prebiotic – with 20 studies showing it promotes growth (colonization) of a broad spectrum of immune-augmenting probiotics such as B. bifidum, B. breve, B. animalis, B. longum, L. acidophilus, L. paracasei, L. casei, L. rhamnosus, Lc. Lactis and B. subtilis but does not have the GI side effects of fiber. Too much harmful or irrelevant bacteria in the gut can prevent nutrients from being absorbed properly – much to the frustration of individuals purposefully eating a nutrient-dense diet to attain good health and well-being. In one clinical study, PreforPro has been shown to encourage a 10-fold increase of B. longum in the ileum and a 100-fold increase in the large intestine. A human clinical study of 15 mg PreforPro substantially accelerated colonization of several beneficial bacteria and showed healthy lipid profile-enhancing activity as well.

However, probiotics and prebiotics are half of the healthy digestion equation. Enzymes are essential in breaking down foods and beverages for processing and absorption of molecular content (good and bad). Your body naturally produces enzymes such as lipase, amylase and protease (that break down fat, carbohydrates and proteins, respectively), but there are a couple of others available to help break down dairy and gluten, a food and food ingredient that, in some, prove challenging to absorb properly.

For example:

  1. A combination of lactase and protease (Dairylytic®) has been shown to break down lactose and protein in dairy products. Lactose is a component of dairy often not well-tolerated; dairy also contains proteins whey and casein, requiring protease to disassemble for fluid digestion. An invitro study showed that the unique enzyme combination was able to break down lactose within 90 minutes, and a specific test (gel electrophoresis) showed even quicker responses – 30 minutes for casein break down and 15 minutes for whey break down. As yogurt often figures prominently in a healthy diet, Dairylytic can help ensure optimal absorption of its nutrients, notably vitamin D and calcium.
  2. Proline-rich and prolyl-enriched peptides found in gluten (the gluten protein groups gliadin and glutenin), necessitate two enzymes — endopeptidase and exopeptidase (Glutalytic®) — for proper breakdown and digestion. Wheat products are known to contain gluten protein groups gliadin and glutenin, and in some people, improperly digested gliadin and glutenin can cause discomfort. Glutalytic has been shown to break down unhydrolyzed gluten peptides into amino acids that are more easily absorbed and utilized. Gel electrophoresis has shown that the administration of the enzyme combination degraded gliadin within 90 minutes. A placebo-controlled study showed that 350 mg of the enzyme combination reduced post-prandial discomforts.
  3. ProHydrolase® is a specific enzyme that breaks down whey protein – still the dominant sports nutrition supplement chosen by men and women who are actively getting into shape. Gel electrophoresis shows that ProHydrolase increases bioavailability of the amino acids, and minimizes amino acids excreted (wasted), meaning more are utilized. A human clinical showed that in those taking ProHydrolase with whey protein had 20% more amino acids in the blood after 270 minutes when compared to those taking whey protein isolate alone.

As the saying goes, you aren’t really what you eat, you are what you digest. When you embark on a healthy diet, don’t rely fully on it to power your health and well-being. Use the proper amounts and types of probiotics/prebiotics and enzymes to help you optimize your nutrition profile – and ensure healthy regularity.

Why Plant-Based Protein is Gaining Popularity

Nutrition fanatics and health-conscious consumers have focused plenty of attention on protein lately. People who are on specialty diets like keto and paleo, seniors who need to maintain muscle mass, active athletes, people who want to lose weight, and more are turning to protein as a solution.

This popular perception of protein’s role in nutrition and health has led many consumers to look for new ways to fit it into their nutritional regimes. Although animal-based protein is complete, 39% of Americans are actively seeking plant-based alternatives to use in their diets, according to a recent Nielsen survey.

What’s driving this demand? A focus on fit lifestyles and a need for better tasting supplements seem to be the main factors behind the push for plant-based protein powders, bars, and more.

Plant Protein Claiming It’s Place in Sports Nutrition
Consumers these days are conscious of what they put in their bodies, and the products that companies launch indicate that sports nutrition marketers are paying attention. In the year ending in October 2017, 40% of new sports nutrition products in the United States bore labels such as “high in protein” or “added protein.” Clearly, the public demands more protein, but not just any old protein will do.

In the same time period, 10% of new sports nutrition products used “vegan” or “100% plant-based” in their marketing. This is significantly higher than the number of new products in the general food and drink industry making the same claim. This suggests that athletes are even more inclined to use plant protein in their diets than the general population.

Plants as a Healthy Alternative
The Nielsen Homescan Panel Protein survey from April 2017 found that 38% of all consumers associate plant-based protein with positive effects on a person’s well-being. Of those who actively try to include more plant protein in their diets, 83% say they do so to improve their health and 62% say that weight management plays a role.

Clearly, many people choose plant-based foods for fitness’ sake, but is that the right move? For some people, it could be.

Some researchers from the International Society of Sports Nutrition Symposium found that, when combined correctly, vegetable proteins can give the body the same amino acids as animal-based protein, but without the cholesterol and saturated fat.

Another study looked at performance in Mixed Martial Arts fighters to see if consumption of plant-based or animal-based protein changed performance. The research found that fighters who supplemented with brown rice protein instead of whey did not suffer losses in performance or body composition. Some of the plant-based fighters even reported an increase in energy.

Taste is a Critical Factor
While health is a major reason many athletes choose plant-based proteins, it’s not the only reason. When it comes down to it, many consumers just like the way this protein tastes. In fact, recent research from Mintel shows that 52% of Americans choose plant-based protein because it just tastes better than the alternatives. As manufacturers continue to find new ways to incorporate plants into great-tasting meals and shakes, you can expect this trend to grow.

Enzymes Help with Any Protein
While the research shows that plant-based proteins can be as healthy as animal-based ones, there’s no one reason that everyone needs to choose one over the other. You should feel comfortable picking the protein that works best for you.

No matter where you get your protein, you can use enzymes and probiotics to maximize every gram. A protein-digesting enzyme product like ProHydrolase® maximizes the performance benefits of protein supplements by ensuring that all the protein gets digested and used for muscle building. It’s effective with both animal and plant-based proteins. In addition, probiotics are becoming increasingly studied and recognized for their benefits to athletes. Deerland’s Bacillus subtilis DE111® was shown in a clinical study to improve body composition and strength when paired with proper post-workout protein nutrition. You can learn more about Deerland’s products to see how to make the most of your protein supplement.

The Difference Between Multi-Strain and Single-Strain Probiotic Supplements

The more scientists learn about the fascinating ecosystem of bacteria living inside of us, referred to as the human microbiome, the more it becomes clear that influencing the good bacteria in your gut can have massive positive effects on your overall health and wellbeing. Most studies on the effectiveness of probiotic supplements revolve around individual strains, and there are far fewer studies that look specifically at the effectiveness of multi-strain probiotic supplements. When shopping for probiotics, you will find both single and multi-strain options widely available. In fact, choosing between the two will probably be one of your first considerations, so it might be helpful to know the differences before deciding on which product is best for you.

The human body is chock full of different kinds of bacteria, both good and bad, and each strain has a different effect on our health. Gut bacteria aid in digestion, are a major part of our immune system, and can help our overall wellbeing in a number of ways. Human clinical studies provide the best method to determine the amount of a particular probiotic needed to provide a health benefit and it is much less complicated to assign cause and effect associations with single strains rather than multi-strain formulations. Single strain products are more likely to contain clinical doses than are multi-strain due to practical constraint, such as cost and dosage size required, although there are some multi-strain clinically researched products in the market.

While most studies on probiotics look at the effects of individual strains, a recent paper examined the results of studies that looked at the effects of supplements containing multiple strains. The paper found that mixtures of probiotics had beneficial effects on multiple health conditions, while boosting overall gut and immune function. Although only 16 studies compared the effect of a mixed supplement against its individual component strains, in 12 of those cases the mixture was shown to be more effective.

Despite these promising results, it must be noted that, at this point in the research, it is impossible to definitively say whether or not multi-strain probiotic supplements are, on the whole, more effective than single strains. A meta-analysis of probiotic research suggests that it is possible to say these multi-strain supplements have been highly effective at calming certain gut conditions, while boosting overall gut and immune performance, meaning that they appear to be the simplest and most effective overall strategy.

Far more studies have been done on the effectiveness of single strains of gut bacteria. One advantage of these single strains is that they allow users to pick and choose which healthy bacteria to increase. Everyone has a different ecosystem of bacteria, and sometimes there is a deficiency or total lack of certain beneficial bacteria. One study found that certain strains could be ‘grafted’ into a gut microbiome that was lacking a particular strain. These findings suggest that bacterial species absent in the gut microbiome of certain individuals can be reestablished, allowing for precise and personalized microbiome reconstitution.

New diagnostic tests based on DNA analysis are being employed to help determine an individual’s microbiome makeup. These new tools may make it easier for the consumer to make informed decisions about probiotic supplementation choices and assist with the development of more effective products based on individual needs.

There are so many factors to consider when selecting the right probiotic supplement for you that it can get a bit overwhelming. One of the very first choices you will face is whether to choose a probiotic supplement with a single bacterial strain or one with multiple strains. Choosing the right bacterial strain or strains can make a major difference in whether or not the bacteria survive and impact the microbiome, giving you the health benefits you are looking for.

At Deerland Enzymes, we take pride in the science-supported dietary supplement formulations we develop with our customers. Although we specialize in customized formulations, we have also developed an exclusive line of university-studied products which can be used as-is, or as the basis for a custom formulation. Our Ph.D. and M.D.-led research and product development teams are on top of the latest technological developments and supplement market trends, delivering the most advanced product lines available. To learn more about formulating a probiotic supplement, visit http://www.deerlandenzymes.com/services/.

Should You Take Probiotics While on Antibiotics?

It’s fairly common knowledge that antibiotics are used frequently to treat a variety of bacterial infections—some of the most common are urinary tract infections, strep throat, and even some pneumonia. Antibiotics kill or prevent bacteria from reproducing, allowing the body’s natural defenses to eliminate the illness-causing pathogen. Not all bacteria and other microorganisms are harmful “germs”. In fact, many microorganisms help our bodies function properly, such as the bacteria that are normally present in our intestines that help digest food, destroy disease-causing microorganisms, and produce vitamins.

While antibiotics are very effective in targeting the pathogenic bacteria that they are prescribed to eliminate, they also wipe out a large amount of the normal, beneficial bacteria that we have in our gut. It’s not unexpected for an infection to cause digestive-related problems, but it’s important to know that the antibiotic itself may also cause issues– most commonly, diarrhea.

Probiotics, on the other hand, are live bacteria that provide health benefits. A wide range of products are sold as probiotics, including foods (like yogurt), drinks and dietary supplements. Many of the probiotic strains are the same as or similar to those that naturally live in our bodies. So, should you take probiotics when you are prescribed antibiotics? Let’s take a closer look.

In a study published in the Journal of American Medical Association, researchers reviewed 63 randomized controlled trials of nearly 12,000 patients and their use of probiotics for the prevention or treatment of antibiotic-associated diarrhea (AAD). Patients were being treated for a range of conditions, from ear infections to sepsis. The study concluded that 42% of patients were less likely to get diarrhea from their antibiotic drugs if they were also taking a probiotic.

Preliminary evidence indicates some probiotics may be helpful in the prevention and treatment of antibiotic-associated diarrhea (AAD), but more needs to be learned. Further study is required in order to determine which probiotics are the most effective and in what dosages. Researchers also need to determine which types of patients would most likely benefit from taking probiotics. Just remember, probiotics are not considered drugs, and are not approved for the treatment of any illness or disease.

Simply put, antibiotics often disrupt the gut’s microflora. The evidence seems to suggest that probiotics can help.

At Deerland Enzymes, we take pride in the science-supported dietary supplement formulations we develop with our customers. Our DE111® strain of Bacillus subtilis is a clinically studied probiotic spore which supports a proper balance of bacteria in the gut. To learn more, visit http://www.deerlandenzymes.com/de111/ today.

Deerland to Launch New Branded Product, Solarplast ® at Engredea/Natural Products Expo West 2018

Deerland is pleased to announce the addition of Solarplast® to the company’s portfolio of science-backed branded products. This innovative product will make its debut at Engredea/Natural Products Expo West, the world’s largest natural, organic, and healthy products event in Anaheim, CA, March 9-11, 2018.

Solarplast is an extract of organic dark leafy greens, which is enzymatically enhanced by a unique and proprietary manufacturing process. It utilizes the power of the chloroplasts found in dark leafy greens to provide a rich source of molecular chaperones and antioxidants, all in a naturally occurring lipid protective coating.
Solarplast supports healthy aging, beauty from within, and general digestive health. “The isolated chloroplasts from dark leafy greens, such as spinach, contain organelles that convert light to energy, working at a cellular level to assist in healthy aging,” explains Dr. John Deaton, vice president of science and technology. Its high concentration of antioxidants, energy molecules, and molecular chaperones are key players, as well. “Each of these components plays a role in healthy aging by repairing the damage done to our bodies through our everyday modern lives,” Deaton adds.

Available as an ingredient for supplement capsules, powder blends, or finished food and beverage products, Solarplast is Deerland’s latest in a long line of science-backed technologies geared toward creating and sustaining a healthier and happier lifestyle. Deerland’s experts will be on hand in booth #3617 to meet you and discuss all the benefits of Solarplast and product formulation ideas. Click here to schedule a meeting.

Genome Sequencing Can Help Identify Undesirable Traits in Probiotic Strains

Genome sequencing is a laboratory process that can be performed with any full copy of DNA. Determining the DNA sequence of an organism can help reveal what each gene making up a genome does, how different genes interact, and how the various parts of the genome are coordinated. By breaking down the sequence, probiotics can be tested for safety and effectiveness, as well as the presence of undesirable traits such as deleterious genes, antibiotic-resistant genes, and plasmids. Sequencing essentially reveals everything there is to know about a bacterial strain.

First, genome sequencing helps identify any deleterious genes that may be present in a probiotic.  Deleterious genes can cause health problems that compromise the capacity of afflicted individuals.

Breaking down the genomic sequence can also identify if the bacteria contains antibiotic-resistant genes. It is important that a supplemental probiotic NOT contain antibiotic-resistant genes. This may seem counterintuitive; shouldn’t you want your probiotic to survive in the gut?  Of course.  However, the fact is that gut bacteria can transfer genetic material among one another. The undesirable bacteria in the gut could acquire antibiotic-resistant genes from other, often harmless, bacteria. Because bacteria containing antibiotic-resistant genes do not respond to specific antibiotics, an infection may be untreatable if caused by antibiotic-resistant bacteria. The increasing number of life-threatening infections caused by antibiotic-resistant bacteria is triggering a rapidly growing global health problem.

Finally, the sequence examines plasmids present in a probiotic strain. A plasmid is a naturally occurring small DNA molecule within a cell that can replicate independently. When a bacterium divides, all the plasmids contained within the cell are copied, such that each daughter cell receives a copy of each plasmid. Bacteria can also transfer plasmids to one another through a process called conjugation. The genes carried in plasmids provide bacteria with genetic advantages, such as resistance to antibiotics or heavy metals—while these new traits may provide an advantage for the organism, they may carry negative consequences for the host.

Genome sequencing is a beneficial tool to better understand any microorganism, including a probiotic. Not only does it help identify any undesirable traits, sequencing reveals genes that support beneficial functions, such as the production of IgG and IgA antibodies for immune response. Armed with the exact makeup of a probiotic, product formulators can make informed decisions and feel confident about the safety and function of the strains they choose for supplement products.

As a producer of probiotic solutions, Deerland Enzymes and Probiotics has put its DE111® probiotic to the test for undesirable traits. Through Deerland’s partnership with Cornell University, DE111 has been fully sequenced for safety and has been uploaded to GenBank, the National Institutes of Health genetic sequence database. By applying genome sequencing to probiotic research, Deerland is able to verify that the highly effective strain of Bacillus subtilis DE111 contains no undesirable traits.

DE111 offers immune system support and helps maintain a healthy gut. Learn more about DE111 and why it’s a superior probiotic at http://www.deerlandenzymes.com/de111/.

Have a (Healthy) Heart!

February is national heart health awareness month, and the media has done a very effective job of delivering key messages to adult Americans about how and why to take care of their cardiovascular systems…especially those who have a family history of heart disease, have spent years smoking, and/or have spent years being obese and inactive (and who have lost weight or are losing weight).

There are startling statistics about the perils of heart disease in American adults (courtesy of the American Heart Association), especially when it comes to women:

  • 90 percent of women have one or more risk factors for developing heart disease.
  • Since 1984, more women than men have died each year from heart disease and the gap between men and women’s survival continues to widen.
  • An estimated 44 million women in the U.S. are affected by cardiovascular diseases.
  • Women have a higher lifetime risk of stroke than men.

But here’s a statistic that we can all find encouraging: 80 percent of heart disease and stroke events may be prevented by lifestyle changes and education.

Beyond dietary changes such as adding omega 3 EFA-containing foods (marine and plant based), cutting down on sodas, energy drinks, alcohol and coffee, and exercising – taking heart-healthy supplements also strengthen the foundation for promoting cardiovascular wellness.

Supplements known for promoting heart health are DHA/EPA, tocotrienols/tocopherols (vitamin E), coenzyme Q10, phytosterols and red wine polyphenols – but there are enzymes that help too.

There are enzymes that science suggests are cardioprotective. For example, bromelain has been shown in some studies to reduce blood platelet aggregation (clumping). This is important because blood clumping reduces blood flow to and from the heart.

The enzyme nattokinase also has cardio benefits: human studies have found that this enzyme may promote healthy blood pressure and may reduce clotting factors. Additionally, the proteolytic enzymes bromelain, nattokinase (and a few others) have antithrombotic, anticoagulant and anti-inflammatory activities, which make them valuable in overall cardiovascular-support formulas.

Other heart-friendly supplemental enzymes are lipase, which breaks down fat, such as triglycerides, and thus improves fat utilization; and papain, which supports normal inflammatory response.

Additionally, free radicals can contribute to cardiovascular stress. Free radicals are highly unstable molecules that oxidize other molecules – and oxidation is an undesirable reaction in the body, which can cause a host of problems if not held in check via antioxidants. Free radicals are produced in the body normally as part of metabolism, but when oxidized can lead to oxidative stress by the constant production of free radicals.

The body has an antioxidant defense system that helps maintain a healthy balance of reduced/oxidized antioxidants, and research suggests that maintaining this system may reduce development of disease. Glutathione, the most researched and protective molecule, and cysteine, are key components of this system.

The glutathione (GSH) antioxidant system – a critical component of a proprietary enzyme supplement formula, ThioZyme®AO – contributes directly to the disarming of reactive oxygen compounds and maintains, in reduced active form, vitamins C and E, which also exert an antioxidant effect.

Enzymes definitely provide more value to human health than aiding in digestion – cardiovascular wellness is a lovely bonus!

How to Manage Inadvertent Exposure to Gluten

Millions of people around the world suffer from allergies or intolerance to gluten. To avoid a potentially serious reaction, many of these individuals avoid gluten in their diets, including products that could possibly contain trace amounts of gluten. Despite best efforts, however, gluten can still be accidentally ingested. Gluten is not inherently difficult to digest for those with a healthy digestive system, but those individuals who are gluten intolerant can experience extreme discomfort, with symptoms that typically include a distressed GI tract and may manifest similar to irritable bowel syndrome (which can vary in severity dependent on the amount consumed and sensitivity level), and more severe reactions, such as rashes and nerve pain. Fortunately, there are measures that can be taken to help manage these symptoms, along with methods to better prepare the body to handle such occurrences.

Gluten actually consists of several different proteins, with the two main being gliadin and glutenin. Due in part to gliadin’s large peptide chain, gluten proteins can be extremely difficult for some people to digest, hence the term gluten intolerance. Undigested gluten may trigger an immune response in gluten intolerant individuals which, depending on the individual’s sensitivity, can cause the immune system to attack the inner lining of the small intestine. But maintaining a 100% gluten-free diet is extremely difficult. Many different foods contain gluten, and due to the nature of modern food production, it is virtually impossible to guarantee that no cross contamination occurs. These factors mean that accidental or inadvertent exposure to gluten is a very real, and for those with gluten intolerance potentially serious, possibility. However, there are options that offer some protection from accidental gluten exposure.

If a gluten intolerant individual inadvertently ingests gluten, there is no miracle antidote. Because everyone’s body reacts differently, there isn’t a quick fix; yet, by keeping hydrated and taking probiotics and digestive enzymes, it is possible to prevent and/or relieve symptoms. Digestive enzymes and probiotics have shown promising results in helping to better digest gluten proteins. Digestive enzymes target those difficult to digest peptide bonds in gluten proteins by breaking them down, making them easier to digest, while a regular intake of probiotics is essential for a healthy, robust gut that is better able to digest the broken down gluten proteins. Proactive measures such as these can also safeguard against the potential side effects of accidental consumption.

In addition, there are a few natural aids available to help manage intestinal symptoms after gluten ingestion. Drinking green or peppermint tea can ease a churning stomach, and marshmallow root can sooth stomach and gas pain. Studies have also shown that fasting for a couple of days after ingestion may help ‘reset’ your immune system; however, check with your doctor prior to trying this approach.

Even though there is no magic solution to inadvertent gluten exposure, it is possible to prepare your body for the worst. Working with a physician to develop a long-term strategy to rebuild and maintain gut health may include diet changes augmented by supplements, particularly probiotics which are essential for healthy, efficient digestion, and digestive enzymes which are specially formulated to combat those tough to break down peptide chains in gluten proteins. Using these tools to boost your digestive tract can help soften the side effects of exposure for those with gluten intolerance, and help others who simply wish to support their bodies’ natural digestion process.

Glutalytic is an enzyme supplement that goes beyond the traditional DPP IV (dipeptidyl peptidase IV) enzyme, offering superior degradation of the gluten proteins that cause immune responses. This unique proteolytic enzyme blend targets the internal and external peptide bonds that make up the gluten protein, helping to protect in the event of gluten ingestion. To learn more about Glutalytic and how it works, visit http://www.deerlandenzymes.com/glutalytic/.

DE111®: Promotes Healthy Regularity

Nobody really likes extremes – such as extremely hot and humid days in the summer to bitter, Arctic cold in the winter, or a too-sweet or too salty food. And, even occasional constipation and its opposite, diarrhea, is no picnic, either.

The “occasional irregularity” when it does occur, swiftly causes discomfort, sometimes even angst, depending upon the person’s situation (working outdoors, for example, and not being near a bathroom when the “feeling” hits.)

The gastrointestinal system is often quite persnickety. It is somewhat akin to a highway – sometimes traffic snarls and clogs, and sometimes when it’s empty, there’s always that show-off speeder who zooms by.

When one deals with both on a more frequent basis, this is the hallmark of irritable bowel syndrome (IBS), which is a medical diagnosis. In absence of IBS, people can become constipated due to medications (antidepressants, pain relievers, iron supplements), lack of sufficient fiber in the diet and hormone fluctuations. Occasional diarrhea not caused by pathogenic bacteria or virus is caused by stress and anxiety (which alters hormone release affecting the GI tract), some prescriptions, and some foods the individual may be sensitive to.

Preventing the occasional irregularity is desirable for multiple millions of healthy Americans who just don’t have time for “bathroom issues.” And, we have a new study, published in the Journal of Probiotics & Health, that shows our DE111® is such an effective solution.

The study included 50 individuals who supplemented with a placebo or one capsule of Bacillus subtilis DE111® supplying 1 billion CFU for 105 days. The participants supplied stool samples that were scored based on the Bristol Stool Chart index, kept a detailed food diary and filled out questionnaires.

The DE111 supplemented group experienced a modulation of bouts of constipation and diarrhea, showing a healthier bowel index – but no change in alternating constipation and diarrhea for the placebo group. Specifically, the proportion of normal stools increased from 37% to 43% in the DE111 group, while the proportion of normal stools remained the same in the placebo group. Interestingly, men taking DE111 had dramatic results – normal stools in this group inclined from 56% to 80%. The supplement also delivered similar impact on those participants 30 and older.

For consumers mindfully living a healthy lifestyle, the occasional extreme of constipation and diarrhea can be less than, well, occasional.

About DE111®
DE111 is a genome-sequenced and clinically tested strain of Bacillus subtilis, a probiotic spore that supports digestive and immune health. The genome sequencing confirmed the strain contained no plasmids, antibiotic resistant or deleterious genes; the human clinical studies showed the strain’s ability to control microbial populations, aid in digestion and maintain general health. DE111 is able to form spores that protect the microbes from harsh conditions until they enter an environment ripe for germination, such as the GI tract. Because of this spore-forming ability, DE111 remains viable under a wide temperature and pH range, making it ideal for use in supplements as well as food and beverages.